Top of pagePATHOGENIC MECHANISMS AND MOLECULAR BASISFactor V Leiden is a genetic disorder seen as an a poor anticoagulant response to APC. APC is an instinctive anticoagulant protein that cleaves and inactivates procoagulant Factors Va and VIIIa, Thereby downregulating further thrombin demographic.5,6 APC inactivates Factor Va by cleavage at three different protein positions: R (Arginine) […]