Mechanistically, Actinin 3 deficiency triggers an increase in oxidative muscle metabolism through activation of calcineurin, Which likely confers the appropriate effect. This work therefore suggests that actinin 3 deficiency reduces muscle strength performance, But ameliorates the progress of dystrophic pathology.ResultsACTN3 genotype modifies strength and durability in ambulant DMD patientsTo assess muscle function in DMD, We […]