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Top of pageIntroductionEnhancer of zeste homolog 2 (EZH2) established fact to be a histone modifier protein that functions as a methytransferase at lysine 27 of histone H3 (Cao et ing, 2002). EZH2 is also a member of the polycomb group of proteins and is one of the polycomb repressive complex 2 (PRC2) Subgroup (Schuettengruber et ing, 2007), And EZH2 has a huge role in X chromosome inactivation (Plath et al, 2003). but bear in mind, There have been several reports that overexpression of EZH2 occurs in various malignancies and that it is a member of a poor outcome in prostate cancer and breast cancer (Varamb’sly et al, 2002; Kleer et ‘s, 2003). In an attempt to discover the functional role of EZH2 overexpression in cancer tissue, We have already indicated that EZH2 downregulates important genes, much like E cadherin and RUNX3, By bettering histone H3K27 trimethylation, which suggests that it may be an oncogene (Fujii et al, 2008; Fujii then Ochiai, 2008). on the other hand, The mechanism of EZH2 overexpression in numerous cancer cells remains unclear. Although overexpression of EZH2 protein detected by immunohistochemical staining in various clinical tissue samples is a member of a poor outcome (Bachmann et ing, 2006), The mechanism responsible for right after in rates of cancer cell positivity between individual cases also remains unclear.
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