Top of pageAbstractPrevious observations of the anatomical distribution and medicinal profile of the dopamine D3 receptor (DRD3) Have indicated its great role in antipsychotic drug action. Risperidone, a suitable first line atypical antipsychotic agent, Exhibits a relatively high affinity for this receptor. recent reports have reported an association of the Ser9Gly polymorphism in the DRD3 gene with therapeutic response to risperidone, But the outcome was inconsistent. We therefore postulated that the Ser9Gly polymorphism might be in linkage disequilibrium with an invisible variant that exerts a direct influence on risperidone efficacy. the present study genotyped eight single nucleotide polymorphisms (SNPs) Distributed in the DRD3 gene and examined five of these for association with treatment outcome, Following an 8 week time period risperidone monotherapy in 130 schizophrenic patients from mainland China. Clinical symptoms were assessed pre and post the treatment period, even though Brief Psychiatry Rating Scale (BPRS). The confounding effects of non pro line nfl jersey genes were estimated and the baseline symptom score was included as a covariate for adjustment. Neither was any association observed between the five polymorphisms and healing in total BPRS scores nor was any combined effect of these variants detected in the haplotype analysis. Given the tight correlation between the clinical potency and the D2 binding affinity of the normal neuroleptics (Creese et al, 1976; Seeman et ‘s, 1976), The dopamine D2 receptor is assumed to serve as a principal target for antipsychotic action. In vivo imaging studies have further demonstrated the importance of dopamine D2 receptor occupancy in predicting antipsychotic response and side effects (Remington furthermore Kapur, 1999). The advent of novel antipsychotics and the similarity of additional dopamine receptor subtypes, but unfortunately, Have allowed for new insights into the wider diversity of pharmacological actions of antipsychotic drugs.
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