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Because neurotrophic factors are vital activating axonal growth33, The vimentin mediated release of neurotrophic factors might be involved in the axonal growth that is induced by vimentin injection. of course, Our previous in vitro data showed that vimentin did not improve the neuronal secretion of IGF1, IGF2 and blood insulin, Which are physical ligands for IGF1R19. as well as, Our unpublished in vitro data demonstrated that vimentin treated astrocytes and vimentin treated microglia do not secrete axonal growth facilitators. This finding suggests that the vimentin induced axonal growth and motor function improvements cheap that were observed in SCI mice might not be mediated by other neuron, Astrocyte or microglia derived neurotrophic motives. Whether extracellular vimentin influences additional cell types in SCI mice requires further exploration.
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