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The cellular oscillator is composed of a positive (time and BMAL1) And a damaging (PER1 since CRY1, 2) limb. wall clock heterodimeres, Through binding to E box elements, Drive the transcribing of several genes: Cry1, Cry2, Per1, Per2, Per3, Rev Erb Ror and countless CCGs. After dimerization PERs and CRYs undergo nuclear translocation inhibiting CLOCK transcription.
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